听力与言语-语言病理学

行为科学

医学伦理学

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  • Isogenic Strains of PHYCOMYCES BLAKESLEEANUS Suitable for Genetic Analysis.

    abstract::The progeny of crosses between wild-type strains of Phycomyces usually do not exhibit all of the expected genotypes from meiosis. By backcrossing, we have isolated a new (+) mating-type strain, A56, which is nearly isogenic with the (-) wild-type NRRL1555 commonly used in Phycomyces research. Tetrad analysis of the ba...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Alvarez MI,Eslava AP

    更新日期:1983-12-01 00:00:00

  • Genetic mapping of IS200 copies in Salmonella typhimurim strain LT2.

    abstract::The wild-type Salmonella typhimurium strain LT2 contains six copies of the insertion sequence element IS200 which is unique to Salmonella. We have determined the chromosomal locations of all six copies of IS200 in strain LT2. This was done by mapping the positions of Tn10 elements inserted near each copy of IS200. Suc...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Lam S,Roth JR

    更新日期:1983-12-01 00:00:00

  • Virility Deficiency and the Sex-Ratio Trait in DROSOPHILA PSEUDOOBSCURA. I. Sperm Displacement and Sexual Selection.

    abstract::The Sex-Ratio (SR) phenomenon is associated with the X chromosome of many species of Drosophila. Males carrying SR transmit predominantly sperm bearing the X chromosome. SR, therefore, has a very significant advantage in segregation. This paper provides an experimental analysis of the role of virility selection in pre...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Wu CI

    更新日期:1983-11-01 00:00:00

  • Recombination in the Vicinity of Insertions of Transposon Tn 5 in MYXOCOCCUS XANTHUS.

    abstract::To test genetic recombination in the vicinity of insertions of the transposon Tn5, crosses were performed by transduction between M. xanthus strains carrying different insertions of Tn5. One member of each pair carried resistance to kanamycin (Tn5-Km); the other carried resistance to tetracycline (Tn5-Tc). The distanc...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Sodergren E,Cheng Y,Avery L,Kaiser D

    更新日期:1983-10-01 00:00:00

  • The Response of Enzyme Polymorphisms to Developmental Rate Selection in DROSOPHILA MELANOGASTER.

    abstract::Two strains of Drosophila melanogaster derived from different geographical localities were subjected to selection for fast and slow developmental rate. Four enzyme polymorphisms were monitored for their response to such selection. Significant changes in allele frequencies were effected for the alphaGpdh and 6Pgd polym...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Cavener DR

    更新日期:1983-09-01 00:00:00

  • Genetic and developmental analysis of the locus vnd in Drosophila melanogaster.

    abstract::Genetic and developmental analysis of an X-linked vital locus vnd was undertaken. Embryos hemizygous for the original allele vnd did not hatch and exhibited a disorganized ventral nervous system (VNS). The mutation maps in the region 1B6-7 to 1B9-10, a subregion of an area previously shown to be essential to normal ne...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: White K,DeCelles NL,Enlow TC

    更新日期:1983-07-01 00:00:00

  • Evolutionary relationships of four species of hawaiian Drosophila as measured by DNA reassociation.

    abstract::Four species of the Hawaiian Drosophila planitibia subgroup which are homosequential in their polytene chromosomes are resident on the islands of Molokai, Maui and Hawaii. Comparisons of DNA sequence divergence in these four have been made by hybridization of total single-copy radiolabeled tracer DNA from each of the ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Hunt JA,Carson HL

    更新日期:1983-06-01 00:00:00

  • Alternate-2 disjunction in the german cockroach.

    abstract::The evidence in support of two types of alternate disjunction in translocation heterozygotes from the German cockroach, Blattella germanica (L.), is reviewed. When unique cytomorphological features occur in the translocation figure, the two types of alternate disjunction are identifiable regardless of the angle of obs...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Cochran DG

    更新日期:1983-05-01 00:00:00

  • On the Components of Segregation Distortion in DROSOPHILA MELANOGASTER. II. Deletion Mapping and Dosage Analysis of the SD Locus.

    abstract::Segregation distorter (SD) chromosomes are preferentially transmitted to offspring from heterozygous SD/SD(+) males owing to the induced dysfunction of the SD(+)-bearing sperm. This phenomenon involves at least two major loci: the Sd locus whose presence is necessary for distortion to occur and the Rsp locus which act...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Brittnacher JG,Ganetzky B

    更新日期:1983-04-01 00:00:00

  • Cytoplasmic inheritance of a cell surface antigen in the mouse.

    abstract::Mta is a cell surface antigen of the mouse and serves as a target for specific T killer lymphocytes. Using a killer cell assay, the antigen has been found in 72 strains of laboratory mice and, with one exception, in all tested samples of mice caught in the wild or bred from such, including Mus molossinus, Mus castaneu...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Lindahl KF,Hausmann B

    更新日期:1983-03-01 00:00:00

  • Models of evolution of reproductive isolation.

    abstract::Mathematical models are presented for the evolution of postmating and premating reproductive isolation. In the case of postmating isolation it is assumed that hybrid sterility or inviability is caused by incompatibility of alleles at one or two loci, and evolution of reproductive isolation occurs by random fixation of...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Nei M,Maruyama T,Wu CI

    更新日期:1983-03-01 00:00:00

  • Chromosomal location of genes controlling flavonoid production in hexaploid wheat.

    abstract::Two-dimensional paper chromatography was performed on methanol extracts of leaves of hexaploid bread wheat, Triticum aestivum L. em. Thell. cultivar Chinese Spring, and of the available nullisomic-tetrasomic compensating lines, the tetrasomic lines and the ditelocentric lines. The chromatograms had 27 spots identified...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Neuman PR,Waines JG,Hilu KW,Barnhart D

    更新日期:1983-02-01 00:00:00

  • Genetic characterization of the sufj frameshift suppressor in Salmonella typhimurium.

    abstract::A new suppressor of +1 frameshift mutations has been isolated in Salmonella typhimurium. This suppressor, sufJ, maps at minute 89 on the Salmonella genetic map between the argH and rpo(rif) loci, closely linked to the gene for the ochre suppressor tyrU(supM). The suppressor mutation is dominant to its wild-type allele...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Bossi L,Kohno T,Roth JR

    更新日期:1983-01-01 00:00:00

  • Male Phenotypes and Mating Efficiency in CAENORHABDITIS ELEGANS.

    abstract::Mating behavior in adult male nematodes can be assayed by mating efficiency, i.e., the number of cross progeny sired by males under standard conditions. Mutant males from 220 strains, representing most of the known complementation groups of C. elegans, have been examined for mating efficiency and for anatomical abnorm...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Hodgkin J

    更新日期:1983-01-01 00:00:00

  • Marker-dependent recombination in T4 bacteriophage. II. The evaluation of mismatch repairabilities in crosses within indicator distances.

    abstract::The contribution of mismatch repair to genetic recombination in T4 phage has been evaluated by three independent approaches: (1) testing for non-additivity of recombinant frequencies; (2) measurements of double exchange frequencies in three-factor crosses: (3) comparisons of recombination abilities of mutations occupy...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Shcherbakov VP,Plugina LA,Kudryashova EA,Efremova OI,Sizova ST,Toompuu OG

    更新日期:1982-12-01 00:00:00

  • Meiosis in Drosophila melanogaster, III. The effect of orientation disruptor (ord) on gonial mitotic and the meiotic divisions in males.

    abstract::Orientation disruptor (ord), a meiotic mutant that is recombination defective in females and disjunction defective in males and females, has been analyzed using serial section electron and light microscopy. From analysis of primary spermatocytes we have confirmed that ord males are defective in some aspect of the mech...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Lin HP,Church K

    更新日期:1982-12-01 00:00:00

  • Polycomblike: a gene that appears to be required for the normal expression of the bithorax and antennapedia gene complexes of Drosophila melanogaster.

    abstract::A newly identified gene is described that is required for the maintenance of normal identities in many of the body segments of the fly. The effects of mutants in this gene, which is called Polycomblike (Pcl), suggest that its wild-type allele functions in the regulation of the bithorax gene complex (BX-C) and the Ante...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Duncan IM

    更新日期:1982-09-01 00:00:00

  • Re-interpretation of genetic variation in simocephalus (cladocera, daphniidae).

    abstract::Populations of several co-existing species of Simocephalus were examined electrophoretically at 11 enzyme loci. The prevailing pattern was one of extensive allelic substitution between species and low levels of polymorphism (0-10%) within species. Genetic identity values between species were very low (10-50%). These r...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Hann BJ,Hebert PD

    更新日期:1982-09-01 00:00:00

  • The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. III. Hypomorphic and hypermorphic mutations affecting the expression of hairless.

    abstract::A lethal locus (l(2)br7;35B6-10), near Adh on chromosome arm 2L of D. melanogaster, is identified with Plunkett's dominant suppressor of Hairless (H). Of eight new alleles, seven act as dominant suppressors of H, the eighth is a dominant enhancer of H. One of the suppressor alleles is both a leaky lethal and a weak s...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Ashburner M

    更新日期:1982-07-01 00:00:00

  • Meiotic Diploid Progeny and Meiotic Nondisjunction in SACCHAROMYCES CEREVISIAE.

    abstract::Abnormalities in chromosome number that occurred during meiosis were evaluated with a specially-constructed diploid strain of Saccharomyces cerevisiae. The strain is heterozygous for six markers of the right arm of chromosome V and heterozygous for cyh2 (resistance to cycloheximide) on chromosome VII.-Selection of mei...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Sora S,Lucchini G,Magni GE

    更新日期:1982-05-01 00:00:00

  • Testing neutrality in subdivided populations.

    abstract::Statistical tests of the neutrality hypothesis that are based on the sampling theory of Ewens (1972) require the assumption of panmixia. It is proposed that for a population comprising numerous local populations with weak gene flow among them, tests based on Ewens' theory can be applied separately to samples from each...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Slatkin M

    更新日期:1982-03-01 00:00:00

  • Analysis of the albino-locus region of the mouse: IV. Characterization of 34 deficiencies.

    abstract::Thirty-four independent nonviable c-locus mutations (types cal, albino lethal and cas, albino subvital), derived from radiation experiments, were tested for involvement of nearby markers tp, Mod-2, sh-1, and Hbb: 10, 22, and 2 involved, respectively, none of these markers, Mod-2 alone, and Mod-2 plus sh-1. When classi...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Russell LB,Montgomery CS,Raymer GD

    更新日期:1982-03-01 00:00:00

  • Genetic dissection of clonally inherited genomes of Poeciliopsis: II. Investigation of a silent carboxylesterase allele.

    abstract::According to the ratchet mechanism hypothesis, deleterious mutations should accumulate in clonal genomes of unisexual fish of the genus Poeciliopsis. This study defines one such mutant, a silent carboxylesterase allele (ES-5 degrees) which is found in the heterozygous condition in a particular population of P. monacha...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Spinella DG,Vrijenhoek RC

    更新日期:1982-02-01 00:00:00

  • Intrachromosomal gene conversion and the maintenance of sequence homogeneity among repeated genes.

    abstract::Intrachromosomal gene conversion is the non-reciprocal transfer of information between a pair of repeated genes on a single chromosome. This process produces eventual sequence homogeneity within a family of repeated genes. An evolutionary model for a single chromosome lineage was formulated and analyzed. Expressions w...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Nagylaki T,Petes TD

    更新日期:1982-02-01 00:00:00

  • [HOK], a new yeast non-Mendelian trait, enables a replication-defective killer plasmid to be maintained.

    abstract::The K1 killer plasmid, [KIL-k1], of Saccharomyces cerevisiae is a 1.25 x 10(6) dalton linear double-stranded RNA plasmid coding for a protein toxin and immunity to that toxin. The [KIL-sd1] plasmid is a replication-defective mutant of [KIL-k1] that depends on one of the recessive chromosomal superkiller (ski-) mutatio...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Wickner RB,Toh-e A

    更新日期:1982-02-01 00:00:00

  • Estimation of genetic variability in natural populations of Drosophila simulans by two-dimensional and starch gel electrophoresis.

    abstract::Genic variation in natural populations of Drosophila simulans was surveyed using allozymic and two-dimensional electrophoretic techniques. Consistent with some previous reports, allozymic heterozygosity appeared lower than in the sibling species D. melanogaster (0.07 vs. 0.16). No variation was detected by two-dimensi...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Ohnishi S,Leigh Brown AJ,Voelker RA,Langley CH

    更新日期:1982-01-01 00:00:00

  • Measuring selection coefficients affecting the alcohol dehydrogenase polymorphism in Drosophila melanogaster.

    abstract::This paper describes a perturbation experiment on the frequency of the F and S Alcohol dehydrogenase (Adh) alleles of D. melanogaster. Fifty-four iso-female lines set up from three wild populations and with initial F frequencies of either 0.25, 0.50 or 0.75 were maintained on standard laboratory food medium at 22 degr...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Wilson SR,Oakeshott JG,Gibson JB,Anderson PR

    更新日期:1982-01-01 00:00:00

  • Preferential mating in symmetric multilocus systems: stability conditions of the central equilibrium.

    abstract::Several multilocus models that incorporate both preferential mating and viability selection are studied. Specifically, a class of symmetric heterozygosity models are considered that assign individuals to phenotypic classes according to which loci are in heterozygous state regardless of the actual allelic content. Othe...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Karlin S,Raper J

    更新日期:1982-01-01 00:00:00

  • Mutation at the am locus of Neurospora crassa.

    abstract::Forty-eight new mutations at the am locus of Neurospora crassa have been characterized. Nineteen mutations were induced by UV; of these, eight were missense, two were frameshifts, two were nonsense, three were deletions and four were unidentified. Twenty-nine mutations were induced with nitrous acid; of these, twenty-...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Kinsey JA,Hung BS

    更新日期:1981-11-01 00:00:00

  • Estimating levels of gene flow in natural populations.

    abstract::The results from a simulation model of selection, mutation and genetic drift in a geographically subdivided population are presented. The infinite-alleles mutation model of Kimura and Crow (1964) is asumed, and both advantageous and deleterious mutations are considered. It is shown that the average frequency of an all...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Slatkin M

    更新日期:1981-10-01 00:00:00

  • Estimation of linkage in the presence of multiplicative viability effects.

    abstract::Log-linear analysis of contingency tables is applied to trihybrid backcross data to estimate linkage and viability. Whereas nonadditive viability differences perturb recombination estimates in the classical analysis, this statistical procedure yields maximum likelihood crossover frequency estimates in the presence of ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Clark AG

    更新日期:1981-09-01 00:00:00

  • Autosomal factors with correlated effects on the activities of the glucose 6-phosphate and 6-phosphogluconate dehydrogenases in Drosophila melanogaster.

    abstract::Isogenic lines, in which chromosomes sampled from natural populations of C. melanogaster are substituted into a common genetic background, were used to detect and partially characterize autosomal factors that affect the activities of the two pentose phosphate pathway enzymes, glucose 6-phosphate dehydrogenase (G6PD) a...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Laurie-Ahlberg CC,Williamson JH,Cochrane BJ,Wilton AN,Chasalow FI

    更新日期:1981-09-01 00:00:00

  • Germline hypermutability in Drosophila and its relation to hybrid dysgenesis and cytotype.

    abstract::In its hypermutable state, an unstable singed allele, sn(w), mutates in the germline to two other alleleic forms at a total frequency usually between 40 and 60%. In its stable state, the mutation rate of sn(w) is essentially zero. Its state depends on an extrachromosomal condition indistinguishable from a property cal...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Engels WR

    更新日期:1981-07-01 00:00:00

  • Genetic variability at the esterase-6 locus in natural populations of Drosophila simulans in relation to environmental heterogeneity.

    abstract::The allozymic variation at at the esterase-6 locus examined in fourteen samples of natural populations of Drosophila simulans collected in two different localities. The samples were collected from different species of fruits in the two localities and from banana baits located some meters apart from the fruits. The ana...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: de Albuquerque CM,Napp M

    更新日期:1981-06-01 00:00:00

  • Selection and identification of a spontaneous alien chromosome translocation in wheat.

    abstract::A wheat (Triticum aestivum L. emend Thell) disomic addition line (2n = 6x = 44), SH1-152-2, with a pair of Elytrigia pontica (Podp.) Holub 2n = 10x = 70 [syn. Agropyron elongatum (Host) P.B.] chromosomes controlling blue aleurone color was crossed with a short-statured spring wheat ;Sonora 64' (T. aestivum). Isoline p...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Jan CC,Dvorák J,Qualset CO,Soliman KM

    更新日期:1981-06-01 00:00:00

  • Response to selection at two temperatures for fast and slow growth from five to nine weeks of age in poultry.

    abstract::Cornell Control White Leghorn chicks were grown in a common environment to five weeks of age and selected for fast and slow gain in body weight from five to nine weeks of age at two temperatures, 21.1 degrees (cold) and 32.2 degrees (hot), during which time a constant 50% relative humidity was maintained. All lines we...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Bohren BB,Carson JR,Rogler JC

    更新日期:1981-02-01 00:00:00

  • The isolation of mms- and histidine-sensitive mutants in Neurospora crassa.

    abstract::A simple method of replica plating has been used to isolate mutants of Neurospora crassa that have increased sensitivity to methyl methanesulfonate (MMS) and/or to histidine. Twelve mutants with increased sensitivity to MMS and one mutant with increased sensitivity to histidine showed Mendelian segregation of the muta...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Delange AM,Mishra NC

    更新日期:1981-02-01 00:00:00

  • Genetics of life history in Drosophila melanogaster. I. Sib analysis of adult females.

    abstract::A sib analysis of adult life-history characters was performed on about twelve hundred females from a laboratory Drosophila melanogaster population that had been sampled from nature and cultured so as to preserve its genetic variability. The following results were found. There was no detectable trend with age in additi...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Rose MR,Charlesworth B

    更新日期:1981-01-01 00:00:00

  • Cryptic operon for beta-glucoside metabolism in Escherichia coli K12: genetic evidence for a regulatory protein.

    abstract::Escherichia coli K12 does not metabolize beta-glucosides such as arbutin and salicin because of lack of expression of the bglBSRC operon, which contains structural genes for transport (bglC) and hydrolysis (bglB) of phospho-beta-glucosides. Mutants carrying lesions in the cis-acting regulatory site bglR metabolize bet...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Defez R,De Felice M

    更新日期:1981-01-01 00:00:00

  • IMP1/imp1: a gene involved in the nucleo-mitochondrial control of galactose fermentation in Saccharomyces cerevisiae.

    abstract::In some strains of Saccharomyces cerevisiae, the induction of enzymes of the Leloir pathway, galactose fermentation and growth on galactose depend on mitochondrial function; mitochondrial dependence is elicited through the recessive allele imp1 of the nuclear gene IMP1. The genetic element IMP1 is not allelic to any o...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Algeri AA,Bianchi L,Viola AM,Puglisi PP,Marmiroli N

    更新日期:1981-01-01 00:00:00

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